Indiana opened a 6-point underdog for Wednesday night's game at No. 24 Penn State, one of two Big Ten contests on the betting docket, each featuring a ranked team. The Hoosiers have not conjured up ample scoring in any of four prior contests catching points this season, averaging 60.5 points on 38.3% shooting when priced as underdogs on the oddsboard. No. 14 Michigan State is laying a hefty 17 points to visiting Northwestern in the other B1G matchup. The Spartans own a ridiculous ATS record when hosting unranked conference rivals at Breslin Center recently but are tasked with covering one of their steepest betting lines in nearly two years. In Big East action, DePaul travels to No. 10 Seton Hall, catching double digits against arguably the hottest team in the country. __Big East betting snapshot:__ [Seton Hall reaches summit](https://www.betchicago.com/big-east-betting-seton-hall-college-basketball) Below are odds and betting information to help your Wednesday college basketball handicapping. ## Indiana at No. 24 Penn State (-6, 143) __Tip:__ 8:30 p.m. ET / 7:30 p.m. CT (BTN) __Betting scoop:__ An inconsistent Indiana offense might be set for an off night Wednesday. Archie Miller's squad (15-5 straight up, 10-10 against the spread) has scored more points than its previous effort once all year, putting up 100 following a 91-point performance in a win over Troy in November. Maryland nipped the Hoosiers 77-76 as a 3-point underdog at Assembly Hall on Sunday. Bad news for potential Indiana bettors if the aforementioned trend holds: Indiana is 5-24 SU and 9-19-1 ATS in road Big Ten contests since the 2015-16 shot-clock change when posting 75 points or fewer. Penn State (14-6 SU, 10-9-1 ATS) is coming off a 14-point win over Ohio State and a 9-point victory over Michigan, tipping off a small underdog in each. The victories helped the program re-enter the AP Poll at No. 24 this week following an early-season appearance. During Pat Chambers' tenure, the Nittany Lions tend to come up short when favored against Big Ten teams with better scoring defenses, going 16-16 SU and 12-20 ATS. The team is 1-2 SU and ATS in this situation this season. The Hoosiers allow 66.6 points per game to 69.0 for Penn State. The UNDER has cashed in all four games Indiana has caught points during the 2019-20 campaign and by a deep -12.8 margin. The offense has not scored more than 67 points in any of the matchups. ## Northwestern at No. 14 Michigan State (-17, 139) __Tip:__ 6:30 p.m. ET / 5:30 p.m. CT (BTN) __Betting scoop:__ Michigan State (15-5 SU, 10-10 ATS) has not laid more than 16 points to a B1G opponent since the 2017-18 season. These steep numbers tend to see conference games go OVER the total for Tom Izzo's program. Since 2011, the bet is 17-6 (73.9%) when the Spartans lay at least 14 points in a conference tilt. The Spartans, though, are on a 5-0 UNDER run. Only Nebraska has a less efficient offense than Northwestern (6-13 SU, 7-11-1 ATS) in the Big Ten, the Wildcats averaging 106.2 points per 100 possessions in KenPom's [adjusted ratings](https://kenpom.com/index.php?y=2019). This doesn't instill much confidence for a lot of scoring for a program putting up 60 points or fewer in five of its last six matchups against the Spartans. Michigan State is an eye-opening 20-4 ATS hosting unranked B1G rivals at Breslin Center since January 2016. ## DePaul at No. 10 Seton Hall (-10, 143) __Tip:__ 6:30 p.m. ET / 5:30 p.m. CT (FS1) __Betting scoop:__ DePaul (13-7 SU, 9-9-1 ATS) has not been spotted double digits on the oddsboard against a program other than Villanova since the 2017-18 campaign (Butler). This season, the Blue Demons are a perfect 4-0 ATS when underdogs of +3.5 or more. But DePaul is on a run of poor form due to cold shooting. They are 1-6 SU and 2-5 ATS in their last seven games, sinking just 41.1% from the floor. Seton Hall (15-4 SU, 13-5-1 ATS), which has not gifted 10-plus points to a Big East opponent since February 2018, is one of the hottest teams in the country. Winning nine straight, the team has covered the spread in all of those games but one. The Pirates are about to get even better. Starting power forward Sandro Mamukelashvili, considered coach Kevin Willard's second best player behind Myles Powell, is expected to return for his first game in seven weeks after fracturing his right wrist. Dating back to last season the Pirates are 10-1-1 ATS in conference play. *This story was compiled with the help of queries performed at [SportsDatabase](https://sportsdatabase.com/).* __Bookmark us:__ [College basketball betting](https://www.betchicago.com/ncaa-basketball-betting)