The public is backing MVP favorite Russell Wilson and the Seahawks as a 6.5-point underdog for Monday night's game (8:15 p.m. ET/7:15 p.m. CT, ESPN) in San Francisco and based on Seattle's dominance in primetime games it's easy to see why. The Seahawks are the best team in the NFL straight up in primetime games (TNF, SNF, MNF) since 2016, going 11-2-1 SU and 10-2-2 against the spread. At FanDuel, 77% of tickets and 69% of dollars wagered in the point spread market is backing Seattle (7-2 SU, 4-5 ATS), but the market as a whole has moved from as low as 5.5 to now 6.5, indicating sharp action on the home favorites. Sure enough, one respected bettor at the South Point in Las Vegas wagered $33,000 on the Niners early in the week at -5.5. San Francisco (8-0 SU, 5-3 ATS) might be the last of the unbeaten teams in the NFL, but its perception still isn't respected due to strength of schedule concerns. Against the lowly Cardinals last Thursday, newcomer Kenyan Drake rushed for 110 yards on 7.3 yards per carry. If Drake can shred the 49ers, what's Seattle's run-first offense going to do? The problem is, the Seahawks defense has been consistently worse this season, ranking 27th in the league in DVOA (Defense-adjusted Value Over Average) for total defense despite facing the fifth-easiest schedule based on opponent records and eighth-easiest based on DVOA. __Listen:__ [Oddsmaker breaks down Week 10](https://www.betchicago.com/bet-pro-football-podcast-betindiana-week-10-bears-lions) The 49ers might have the league's most run-heavy offense, but the constant running clock hasn't prevented high-scoring games the past two weeks. The Niners actually are one of five teams to have an explosive pass-play rate above 11% this season. Jimmy Garoppolo has quickly found a big-play target in Emmanuel Sanders to go along with George Kittle (questionable), who has had at least six catches in all but two games this season. Former Patriots WR Josh Gordon will make his debut with the Seahawks on Monday, but his role and matchup with the No. 1 pass DVOA defense make him hard to trust in DFS slates. The 49ers defense has allowed 118 pass yards per game over the past three games, but if there is anyone that has exploit it, it's Wilson. Plus-350 to win the MVP at the Westgate SuperBook. Wilson has 25 total TDs and just one pick. His 22 TD passes lead the league entering Sunday and so does his passer rating of 118.2. Will Wilson target former teammate Richard Sherman, who is No. 1 in the league in passer rating against, according to Pro Football Focus. Sherman, who usually plays the left side of the field, has earned plenty of respect from Wilson. “I know not to go over there too much,” Wilson told reporters. “He’s as good as it gets over there. Got a lot of respect for Sherman and how he plays the game. He really understands things and sees things well. You’ve got to be really smart when you go over there.” __MORE:__ [Our complete NFL betting news, information and insight](https://www.betchicago.com/nfl-betting) Sherman isn't the only outstanding corner for the Niners. Slot cover man K'Waun Williams is allowing the fourth-lowest passer rating on balls thrown into his slot coverage, [according to](https://www.rotoworld.com/) Rotoworld. Without linebacker Kwon Alexander (pec), the Niners are vulnerable to tight ends and backs out of the backfield, making Jacob Hollister a player to watch on Monday. The total is the betting market that has seen the most movement. Aided by a release of the OVER [from analyst](https://www.sharpfootballanalysis.com/) Warren Sharp, the total has adjusted from as low as 44.5 in some shops up to as high as 48. OVER is 13-5 in Seahawks' last 18 games overall and is 10-3 in their last 13 vs. NFC teams. Here are four other betting trends to be aware of on Monday night. ## Seahawks at 49ers betting trends • Seahawks are 9-1-1 ATS in their last 11 games as an underdog. • OVER is 8-2 in Seahawks' last 10 road games vs. a team with a winning home record. • 49ers are 9-19-1 ATS vs. a team with a winning record. • OVER is 8-3 in 49ers' last 11 vs. a team with a winning record. __Super Bowl 54 odds:__ [Ravens flying high up board](https://www.betindiananews.com/super-bowl-54-odds-update-ravens-soar/)